Scientists develop self-sustaining process to produce chemicals from biomass, for uses such as making biofuels, pharmaceuticals; process extracts levulinic acid from cellulose, reuses one byproduct as catalyst, is powered by combustion of its own waste

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TOKYO , April 11, 2023 (press release) –

The research team of Tokyo University of Agriculture and Technology (TUAT) has designed and developed a novel recycling process for producing biomass-derived chemicals by reusing the by-products of the target product. In this study, the research team demonstrated a self-sustaining process that minimizes the usage of external utilities in the chemical process by numerical simulations. This achievement has significantly contributed to energy conservation by reusing by-products, which had been disposed of in the conventional process in the chemical process to ensure profitability. In addition, while previous processes were designed on a large scale, this study was designed with a biomass supply feasible in all regions. This is a completely different approach from conventional processes. With this achievement, we can significantly reduce petroleum usage in chemical processes to establish a recycling-oriented society in the future. In addition, for regional revitalization, it is expected to create a chemical industry for local production for local consumption using agricultural and forestry waste in mountainous regions.

The results have been published in Chemical Engineering Research and Design on March 1st, 2022.

Biomass is the renewable carbon resource that can replace fossil resources in chemical production. Among the biomass-derived chemicals, levulinic acid (LA) is attracting attention as a platform chemical because it can be synthesized from cellulose, which makes up about 50% of woody biomass, and is a precursor for a wide range of substances from pharmaceuticals to bio-fuels. Conventional LA production processes from biomass are large-scale processes with an annual biomass supply of more than 120,000 tonnes, and had challenges in effectively utilizing all biomass resources.

In response, this research team has developed a process that minimizes the supply of external utilities by reusing by-products produced during the production of LA from biomass as much as possible while still being able to supply all of the required energy from the combustion of by-products. Specifically, by reusing the by-product formic acid as a catalyst, using a chemical called furfural obtained from biomass as an extraction solvent to purify LA, and combusting the solid by-products, the total process energy was reduced and supplied by itself. Furthermore, it was found that the excess solid by-products could be effectively utilized for building materials and other purposes. We also found that using river water could provide all the cooling needed. The amount of river water is less than 0.12% of the minimum annual volume flow in the middle reaches of the Naka River in Tochigi Prefecture, located in a rural area of Japan.

Regarding economics, the minimum selling price of LA produced by this process was $9.59 per kilogram, which was higher than the market price of $7.17 per kilogram. The reason is due to the fact that this process allows for thin profit margins to some extent, which is an advantage of large-scale processes, and also because no separation and purification of by-products are performed. According to the above points, it can be said that the results of this research indicate that this process can be fully implemented in society for a locally produced and consumed chemical industry using agricultural and forestry waste in mountainous regions.

Credit:  Chihiro Fushimi/TUAT


This work was supported by the Doctoral Program for World-leading Innovative & Smart Education of Tokyo university of Agriculture and Technology (WISE Program of TUAT): "Excellent Leader Development for Super Smart Society by New Industry Creation and Diversity" granted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.

For more information about the Fushimi laboratory, please visit

Original publication

Design and Techno–Economic Analysis of Levulinic Acid Production Process from Biomass by Using Co-product Formic Acid as a Catalyst with Minimal Waste Generation
Ryu Ukawa-Sato, Nanami Hirano, Chihiro Fushimi
Chemical Engineering Research and Design 192, 389-401, 2023

About Tokyo University of Agriculture and Technology (TUAT)

TUAT is a distinguished university in Japan dedicated to science and technology. TUAT focuses on agriculture and engineering that form the foundation of industry, and promotes education and research fields that incorporate them. Boasting a history of over 140 years since our founding in 1874, TUAT continues to take on new challenges boldly and steadily promote fields. With high ethics, TUAT fulfills social responsibility in the capacity of transmitting science and technology information towards the construction of a sustainable society where both human beings and nature can thrive in a symbiotic relationship. For more information, please visit

Expert Contact

Chihiro Fushimi, Ph.D.
Professor, Department of Chemical Engineering, TUAT, Japan

Media Contact

Ken-ichiro Saitoh
Tokyo University of Agriculture and Technology

To access the original peer-reviewed study in Chemical Engineering Research and Design, click here

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