Nanofibrillar cellulose firm UPM Biomedicals signs distribution agreement with Brinter for GrowInk bioinks in multiple countries including the US, Canada, most of Europe; Brinter develops cartilage implants using their patented 3D bioprinting technology

Sample article from our Health Care Sector

December 21, 2023 (press release) –

UPM Biomedicals, the forerunner in producing high quality nanofibrillar cellulose for life science and clinical applications, has signed an extensive distribution agreement for GrowInk™ bioinks with Brinter Inc, a Finnish-US medtech/biotech company focusing on the development of cartilage implants using their patented 3D bioprinting technology.

The agreement grants Brinter Inc the distribution rights of GrowInk bioinks in United States, Canada, Mexico, Finland, Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Netherlands, Malta, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Australia and New Zealand.

Dr. Johana Kuncova-Kallio, Director, UPM Biomedicals: “We are happy to enter into distribution agreement with Brinter, a Finnish-US company with global outreach. With Brinter, we are looking forward to entering even more company laboratories and hospitals with our GrowInk™ bioinks. Let’s wave the “made in Finland used around the globe” flag together!”

Dr. Eva Mueller, Head of Products, Brinter Inc: “This collaboration marks a significant milestone in advancing the field of 3D bioprinting and regenerative medicine together. We are excited about the impact this partnership will have on driving innovation in the life science and clinical sectors.”

UPM Biomedicals’ GrowInks are animal free, biocompatible, and ready-to-use hydrogels that can be mixed directly with cells for bioprinting applications. The two main components in GrowInks are nanofibrillar cellulose and water, providing a fully defined matrix for living cells to grow in. The bioinks can be customised by the addition of molecules, such as growth factors or adhesion proteins, or other biomaterials to customise the cell culture matrix for the specific needs of different cell types.

Ready-to-use and customisable GrowInks mimic the in vivo environment supporting cell growth and differentiation. Over 150 different cell types have been cultured in nanofibrillar cellulose. They can easily be diluted to provide a wide range of stiffnesses that can be matched to the requirements of cells. GrowInks are room temperature stable, and they can be used with or without a crosslinking agent depending on the application. GrowInks enable cell printing layer-by-layer with high-precision cell positioning.

GrowInk is available in three different versions:

  • GrowInk-N – natural opaque bioink made of pure nanofibrillar cellulose.
  • GrowInk-T – transparent, anionic nanofibrillar cellulose bioink for advanced imaging applications. GrowInk -T can be optionally cross-linked with Calcium chloride (CaCl2) to harden the printed structures.
  • GrowInk-ALG – nanofibrillar cellulose based bioink with alginate that can be cross-linked.

Advances in 3D bioprinting have been outstanding in the past decade. The technology is becoming widely used for various applications, and 3D bioprinting is already important in areas such as cancer research, where tumour models can be printed to test their response to different treatments. More recently, the use of this technology has been explored in a clinical setting, with the possibility of printing tissues or organs that can then be transplanted into patients. Use of animal-free raw materials for bioink formulations make transplants into humans much more effective and reduces the possibility of an immune response or rejection by humans.

UPM Biomedicals is the forerunner in producing high quality (ISO13485) nanofibrillar cellulose for life science and medical applications. Our nanofibrillar cellulose (NFC) can be used in numerous forms and acts as an underlying building block for bridging the worlds of biomaterials, biomanufacturing and medicine. UPM Biomedicals collaborates with universities, research centres and industrial partners on future innovations and products in the field of high throughput drug screening, personalized medicine, advanced cell therapies, 3D bioprinting, tissue engineering and advanced wound care.

For further information please contact:
Johana Kuncova-Kallio, Director, UPM Biomedicals, tel. +358 40 612 6300
Tony Kiuru, Senior Manager, Business Development, UPM Biomedicals, tel. +358 40 708 5100

UPM, Media Relations
Mon-Fri 9:00–16:00 EET
tel. +358 40 588 3284
media@upm.com

UPM Biomedicals
UPM Biomedicals makes products for life science and clinical uses based on our patented nanofibrillar cellulose technology from birch wood pulp. Our clinical products are manufactured under ISO 13485 quality management system. Our animal-free biomaterial finds applications in 3D cell culture, drug discovery and screening, cell storage and transportation, 3D bioprinting, tissue engineering, advanced wound care, implants, personalized medicine, and novel drug formulations. We also provide cell culture protocol development and workflow integration support services for our life science customers in adopting our technology. www.upmbiomedicals.com

Brinter Inc
Brinter Inc is a trailblazing American-Finnish biotech/medtech company recently relocated to Winston-Salem, North Carolina, and dedicated to engineering regenerative cartilage for human BioMods™/implants. The pioneering Brinter team is developing and bioengineering personalized human BioMods™ for facial reconstructions and orthopedics. Their patented technology, materials, and regenerative medicine approach will change how we treat cartilage injuries in the future. Brinter is a member of the RegeneratOR Innovation Accelerator at the Wake Forest Institute for Regenerative Medicine. The goal is to break through current technological limitations and improve the quality of life for patients suffering from cartilage injuries or loss. For more information, visit www.brinter.com

UPM
We deliver renewable and responsible solutions and innovate for a future beyond fossils across six business areas: UPM Fibres, UPM Energy, UPM Raflatac, UPM Specialty Papers, UPM Communication Papers and UPM Plywood. As the industry leader in responsibility, we are committed to the UN Business Ambition for 1.5°C and the science-based targets to mitigate climate change. We employ 17,200 people worldwide and our annual sales are approximately EUR 11.7 billion. Our shares are listed on Nasdaq Helsinki Ltd. UPM Biofore – Beyond fossils. www.upm.com

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