March 5, 2024
(press release)
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The presentations will include new preclinical data for a fully human monoclonal anti-Nectin-4 antibody conjugated to a novel topoisomerase I inhibitor and a highly potent and orally administered inhibitor of KRAS G12D that is selective against wild-type KRAS. In addition, preclinical data on a potent and selective BRM (SMARCA2) inhibitor for the treatment of BRG1 (SMARCA4) mutated cancers will be presented in collaboration with Foghorn Therapeutics. Investigational New Drug (INDs) applications are planned for all three programs in 2024. Details on poster presentations are below: Presentation Title: A next generation treatment for Nectin-4 positive cancers - Preclinical characterization of LY4052031, an anti-Nectin-4 antibody, conjugated to a novel camptothecin payload Presentation Title: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models Presentation Title: Discovery of selective BRM (SMARCA2) ATPase inhibitors for the treatment of BRG1 (SMARCA4) mutant cancers About
This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about
Refer to: Megan Talon; megan.talon@lilly.com; 463-209-1470 (Media) Joe Fletcher; jfletcher@lilly.com; 317-296-2884 (Investors) View original content to download multimedia:https://www.prnewswire.com/news-releases/lilly-announces-details-of-presentations-at-2024-american-association-for-cancer-research-aacr-annual-meeting-302079085.html SOURCE
Abstract Number: 1872
Session Date & Time: Monday, April 8, 9:00 a.m. – 12:30 p.m. PT
Session Title: Antibody-Based Technologies and New Inhibitors
Presenter:
Abstract Number: 3316
Session Date & Time: Monday, April 8, 1:30 p.m. – 5:00 p.m. PT
Session Title: Novel Antitumor Agents 3
Presenter: Xueqian Gong
Abstract Number: 3230
Session Date & Time:
Session Title: Epigenetic Targets
Presenter: Janice Lee
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