Consumption of nuts inversely associated with total mortality in US men and women in largest study to date on topic; study, published in New England Journal of Medicine, suggests potential benefit of nut consumption for promoting health, longevity

Cindy Allen

Cindy Allen

Dec 30, 2013 – Business Wire

FRESNO, California , December 30, 2013 (press release) – Largest Study to Date on Nut Consumption and Mortality in New England Journal of Medicine

In a study published November 20, 2013 in the New England Journal of Medicine1, researchers looked at the association of nut consumption with total and cause-specific mortality among 76,464 women in the Nurses’ Health Study and 42,498 men in the Health Professionals Follow-up Study. Consumption of nuts, including tree nuts (such as pistachios, almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, and walnuts), was inversely associated with total mortality in both men and women, independent of other predictors for death. In addition, there were significant inverse associations for deaths due to cancer, heart disease and respiratory disease.

This is the largest study to date to examine the relation between nut consumption and total mortality, and the results are consistent with previous studies, according to senior author, Charles Fuchs, MD, MPH, from the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA. “The findings from our study and others suggest a potential benefit of nut consumption for promoting health and longevity,” reported Dr. Fuchs.

Nuts contain important nutrients such as unsaturated fats, high quality protein, vitamins (i.e., vitamin E, folate and niacin) minerals (i.e., magnesium, calcium and potassium) and phytochemicals—all of which may offer cardioprotective, anticarcinogenic, anti-inflammatory and antioxidant properties.

Previous studies have supported the disease-protective power of nuts, specifically pistachios. Studies suggest that pistachios eaten in moderation may help support healthy blood glucose levels.2 Additionally, the FDA recognizes that eating 1.5 ounces per day of most tree nuts, including pistachios, as part of a diet low in saturated fat and cholesterol may lower the risk of heart disease.3 And for weight maintenance, emerging research suggests that the actual act of opening the shell to eat a pistachio helps to slow down the eating process. The shells appear to serve as a visual cue in reducing caloric consumption. Even though fewer calories (and pistachios) are consumed, there was no difference in satisfaction.4,5

A one-ounce serving of pistachios is 49 nuts, more per serving than any other snack nut, and provides a good source of fiber (3 grams), 6 grams of protein and 11 grams of heart healthy fat all for just 160 calories.

“Cardiovascular disease (CVD) is one of the leading causes of mortality in India. It is estimated that 23.6 million CVD cases will be reported in subjects younger than 40 years of age by 2015, suggesting that young Indians are at higher cardiac risk,” says Wahida Karmally, DrPH, RD, CDE, Associate Research Scientist, Columbia University.

“Several studies have demonstrated that regular consumption of nuts such as pistachios and almonds (about five ounces per week) is associated with a reduced risk of heart disease. Because of their beneficial unsaturated fatty acid profile as well as other nutritional components such as protein, magnesium, potassium, nuts may be incorporated into a healthful dietary pattern low in saturated fat and cholesterol to reduce LDL-cholesterol (bad cholesterol).

“This study further strengthens the value of eating these nuts as a part of a meal or as a snack for wellbeing.”

The study was funded by the National Institutes of Health (NIH) with additional support from The International Tree Nut Council Nutrition Research & Education Foundation (INC NREF). The National Institutes of Health is made up of 27 different components called Institutes and Centers. Each has its own specific research agenda. All but three of these components receive their funding directly from the United States Congress, and administrate their own budgets. NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

About American Pistachio Growers

American Pistachio Growers (APG) is a non-profit voluntary trade association representing more than 550 grower members in California, Arizona and New Mexico. APG is governed by a democratically-elected 18-member board of directors and is funded entirely by growers and independent processors with the shared goal of increasing global awareness of nutritious, American-grown pistachios. The United States has been #1 in global pistachio production since 2008. For more information, please visit

1 Bao, Y., J. Han, F.B. Hu, E.L. Giovannucci, M.J. Stampfer, W.C. Willett, C.S. Fuchs, 2013. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 369:2001-2011.

2Kendall CWC, Josse AR, Esfahani A, Jenkins DJ. The impact of pistachio intake alone or in combination with high-carbohydrate foods on post-prandial glycemia. Eur J Clin Nutr. 2011;65(6):696-702

3United States Food and Drug Administration, Qualified Health Claims: Nuts and Coronary Heart Disease (Docket No 02P-0505)

4Honselman CS, Painter JE, Kennedy-Hagan KJ, Halvorson A, Rhodes K, Brooks TL, Skwir K. In-shell pistachio nuts reduce caloric intake compared to shelled nuts. Appetite. 2011;57:414-7.

5Kennedy-Hagan, Painter JE, Honselman C, Halvorson A, Rhodes K, Skwir K. The effect of pistachio shells as a visual cue in reducing caloric consumption. Appetite. 2011;57(2):418-20.

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