April 14, 2022
(press release)
–
Microbial sciences company
The PDS-08 Pediatric Daily Synbiotic is described as a two-in-one powdered synbiotic. Each of the nine probiotic strains are supported by published dose-response data. The prebiotic is a comprised of short and long-chain fibers. In addition to 18 clinical studies validating strain-specific benefits across gut barrier integrity, gut immune function, dermatological health, and respiratory health, PDS-08 was also the subject of a placebo-controlled, randomized clinical trial recently published online on the pre-peer review MedRxiv site. The pre-print is currently undergoing peer review at a top-tier scientific journal. The new trial included 64 children aged between 3 and 17
Data from the study showed that children experiencing intermittent constipation (less than 5 bowel movements a week) saw an increase in weekly bowel movements without any observed side effects or gastro-intestinal (GI) distress (such as pain, bloating, gas, diarrhea). This is considered a significant finding considering as many as 30% of children struggle with intermittent, constipation-related GI distress. The product is also reported to be the first multi-strain synbiotic to include the pioneering strains, Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706), which were evaluated in a randomized, placebo-controlled, double-blind trial in over 400 school aged children with respiratory difficulties. According to data published in the
The other strains used in the PDS-08 product are: Bifidobacterium breve BR03, B. lactis BPL1, B. longum ES1, Lacticaseibacillus (formerly Lactobacillus) casei BPL4, L. rhamnosus GG, Lactobacillus acidophilus NCFM, and B. animalis subsp. lactis Bi-07. "Over the last decade, the velocity of microbiome science discoveries that transform our understanding of each phase and aspect of a child's health is unprecedented,” stated
Dr.
PDS-08 is the company's first consumer launch since the announcement of its
Available by subscription for
"While there is evidence to support probiotic intervention for select pediatric conditions, the marketing and commercialization are often ahead of the science. In a sea of hyperbolic claims and misinformation, choosing the right probiotic for your child can feel paralyzing,” explained
“With PDS-08, we set out to develop a clinically validated pediatric product to elevate the category and offer a science-first option that parents and pediatricians can trust.” The PDS-08 Pediatric Daily Synbiotic joins Seed's flagship synbiotic for adults, DS-01 Daily Synbiotic, which was developed with Dr
DS-01 is described as a “broad-spectrum probiotic with 24 genetically distinct microorganisms across 12 species, including strains with novel mechanistic data that have been investigated in multiple randomized, double-blind, placebo-controlled human clinical trials”. Available as a dietary supplement, the company recently received IND authorization for a clinical trial in IBS patients with Dr.
Source: MedRxiv‘Pioneering strains’
PDS-08
DS-01
Pre-print published online, not yet peer reviewed. doi: 10.1101/2022.04.07.22273329
“Functional response to a microbial synbiotic in the gastrointestinal system of constipated children”
Authors:
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